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REVIEW ARTICLE
Year : 2020  |  Volume : 3  |  Issue : 4  |  Page : 245-253

Research advances of traditional Chinese medicine in cancer immunotherapy


1 The Research Centre of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
2 The Research Centre of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine; Research Center of Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
3 The Research Centre of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine; Research Center of Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

Correspondence Address:
Prof. Zhiyu Wang
The Research Centre of Integrative Cancer Medicine, Discipline of Integrated Chinese and Western Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/CMAC.CMAC_42_20

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Tumorigenesis are closely associated with the immune function of the human body. Immunotherapy has emerged as a novel and promising treatment strategy in multiple malignancies in the 21st century. Traditional Chinese medicine (TCM) has been extensively used for cancer treatment in China and surrounding countries for it exerts efficient therapeutic effects with few side effects. In recent years, studies have demonstrated that TCM plays a unique and reliable role in regulating tumor immunity. TCM can enhance the antitumor immune response function by regulating the secretion of cytokines, reshaping the balance of immune cells, and regulating immune checkpoints to relieve the immunosuppression. In addition, TCM can reduce the side effects (e.g., cytokine storm) of cancer immunotherapy. Based on the current research of active immunotherapy and passive immunotherapy, this review summarizes the potential applications and existing problems of TCM in tumor immunotherapy. This review may be helpful in illuminating the scientific basis of TCM in tumor immunotherapy, promoting its internationalization, as well as shedding innovating new strategies for the development of tumor immunotherapy.


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